01.05 Protein Kinases, Phosphatases and Signaling Proteins

Half day session organized by Ann Stock

Protein phosphorylation is a widely used strategy in receptor-mediated signal transduction pathways.  This session will examine structure/function relationships in protein kinases, phosphatases and associated proteins.  Interactions with substrates and mechanisms of regulating enzyme activity will be explored.

Confirmed Invited Speakers:

James Hurley (NIDDK/NIH, USA)
A Structural Genomics Approach to Signal Transduction

John Kuriyan (Rockfeller Univ./HHMI, USA)
Structural Studies of Inactivation Mechanisms of Protein Kinases

Cynthia Stauffacher (Purdue Univ., USA)
Structural Interpretations of the Activation, Inhibition and Self-regulation of the Low Molecular Weight Phosphatases

New Speaker:

Gourisankar Ghosh
Structural Basis for the Substrate Recognition and Constitutive Phosphorylation Activity of a Yeast SR Protein Kinase