E0050

Facilities for Structural Biology at the ILL. Peter A. Timmins*, Trevor Forsyth*, Michael Härtlein* and Dean Myles‡, * Institut Laue-Langevin, 6 rue Jules Horowitz, BP156, 38042 Grenoble, France, EMBL - Grenoble Outstation, 6 rue Jules Horowitz, BP 181, 38042 Grenoble Cedex 9 France.

The ILL, as the worlds highest intensity neutron source has unparalleled resources for neutron scattering experiments in all fields of condensed matter research and in particular structural biology.

Three different types of instrument are covered (we do not discuss here the important facilities for the study of macromolecular dynamics using neutron inelastic scattering):

Diffractometers for high and low resolution crystallography and fiber diffraction.

Small angle scattering instruments for solution studies.

Reflectometers for the study of real and model membranes.

In addition to these state-of-the-art instruments the ILL has also recently constructed a laboratory dedicated to the production of deuterium labelled biological macromolecules. This technique is invaluable in all fields of biological neutron scattering both for enhancing contrast, highlighting specific parts of complexes and for increasing the signal to noise ratio particularly in crystallographic and fibre diffraction data.

Details both of the instrument and the deuteration facilities will be given in the poster.