W0050

A Modular Approach to Supramolecular Synthesis. Christer Aakeroy, Alicia Beatty, Brian Helfrich, Chemistry, Kansas State Univ., Willard Hall, Manhattan, KS 66506 USA.

In order to bring crystal engineering to a higher level of refinement and versatility it is necessary to identify reliable supramolecular reactions and synthetic strategies that will allow us to build multi-component heteromeric structures, e.g. binary and ternary supermolecules. We have explored a few simple ideas in the design of ternary cocrystals with well-defined and predictable connectivity, and in the exploration of solid-state selectivity with a view to establishing a foundation for modular and transferable supramolecular synthesis. These ideas will be illustrated with several examples of ternary cocrystals constructed with the help of a variety of new "supramolecular reagents".

C.B. Aakeröy, A.M. Beatty, B.A. Helfrich, A High-Yielding Supramolecular Reaction, J. Am. Chem. Soc. 2002, 124, 14425-14432.

C.B. Aakeröy, A.M. Beatty and B.A. Helfrich, ‘Total synthesis’ supramolecular style: Design and hydrogen-bond directed assembly of ternary cocrystals, Angew. Chem. Int. Ed. Engl. 2001, 40, 3240-3242.