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| Hexamer With Electrostatic CalculationsEric di Luccio
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Description of Image:1-Quinolinate phosphoribosyl transferase enzyme (BNA6) from S. cerevisiae. Quinolinic acid phosphoribosyl transferase (QAPRTase, EC 2.4.2.19) is a 32 kDa enzyme encoded by the BNA6 gene in yeast and catalyzes the formation of nicotinate mononucleotide from quinolinate and 5- phosphoribosyl-1-pyrophosphate (PRPP). QAPRTase plays a key role in the tryptophan degradation pathway via kynurenine, leading to the de novo biosynthesis of NAD (+) and clearing the neurotoxin quinolinate. The image shows the hexameric surface with electrostatic properties. The structure was solved by APBS and visualized and rendered with VMD 1.8.7-beta (Mac OSX). The electrostatic field lines are displayed and are "emerging" out of the 3 active sites. From Comprehensive x-ray structural studies of the quinolinate phosphoribosyl transferase (BNA6) from Saccharomyces cerevisiae; E. di Luccio, and D.K. Wilson, (2008) Biochemistry, 47(13); 4039-50. Epub Mar 6, 2008. | |||||||||||||||||||||||||||||||||||||||||||||||||||
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