Positions Available
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For the most up-to-date listings check the ACA Home Page under the Positions Vacant heading.
http://www.hwi.buffalo.edu/ACA/

Applications Scientist, Single Crystal Diffraction
Bruker AXS, Inc, located in Madison, WI (voted one of the top livable cities in the USA) has a newly defined position for an applications scientist, to extend our business as the leading supplier of single crystal diffraction instruments. This position will work with other scientists in the Madison headquarters, and will be responsible for
* Demonstrating single crystal diffraction instruments and software to potential customers
* Providing complete crystal structure determinations using SMART CCD systems on a wide range of customer samples
* Applications training and support of customers on-site, in the factory, and via email/telephone
* Collaboration on research projects and preparation of material for public dissemination, scientific presentations and publications
* Specifying and testing new and improved products for single crystal diffraction
Requirements for this position include: Ph.D. in chemistry or other physical science, with experience in organic, inorganic or organometallic compounds. Hands-on experience in academic or industrial research environment collecting data and solving single crystal structures; experience with SMART CCD instruments and SHELXTL software a plus. Excellent verbal and written communications skills and ability to work effectively with customers. Bruker offers competitive compensation and benefits and is an equal opportunity employer. Authorization to work in the USA is required. Qualified applicants should contact Sue Byram in the Bruker AXS exhibit area or ACS New Orleans meetings, and/or submit resume and salary requirements in confidence to: Bruker AXS, Inc., Human Resources, 6300 Enterprise Lane, Madison, WI 53719-1173, Telephone 1-800-234-XRAY, FAX 1-608-276-3006, Email lneuenfeldt@bruker-axs.com

Postdoctoral Fellow
The DNA Damage and Repair Group in the Life Sciences Division at Lawrence Berkeley National Laboratory seeks qualified postdoctoral candidates protein structure /function studies. Applicants must possess a Ph.D. obtained within the last three years, be experienced in protein crystallography, recombinant protein expression, purification, and crystallization. The successful candidate will work as part of a multidisciplinary team consisting of molecular biologists, cell biologists, and biochemists. Our Lab has a recognized research program investigating the enzymes, genetics, and biochemistry of mammalian DNA repair. The candidate must be highly motivated, have excellent communication skills, and work well within a team environment. For further technical details contact Dr. David J. Chen by FAX at (510) 486-6816, or by e-mail: DJChen@lbl.gov. Please send applications including CV and names of three references to: David J. Chen, LBNL, MS 74-157, One Cyclotron Road, Berkeley, California 94720.

Postdoctoral Positions
Two postdoctoral positions are available in the laboratory of Michael Rossmann.
Position 1: The first position is for somebody with, preferably, protein, virus, nucleic acid, or other biological macromolecular experience. We are currently working on a variety of viral systems, including rhino- and enteroviruses (both simple +RNA virus genera), parvoviruses (simple ssDNA viruses), toga- and flaviviruses (+RNA enveloped viruses), microviridae (ssDNA bacterial viruses), phi29 and T4 (dsDNA bacterial viruses), and retroviruses. We utilize both crystallographic and cryo-EM (in collaboration with Tim Baker of the neighboring laboratory) techniques. Experience in molecular biology techniques, as well as structural techniques, would be welcome.
Position 2: The second position is for a person with interest in computational macromolecular crystallography. The research will be primarily in developing improved, three-dimensional, methods for the analysis of single crystal X-ray diffraction data of proteins, viruses, nucleic acids, and other large biological complexes. Emphasis will be on data collected at synchrotrons. Previous experience in the development of computational crystallographic techniques and of common computer languages is essential.
We work in collaboration with CHESS and the ADSC CCD company. The work is not proprietary. All novel results are published, and the resultant computer codes are made freely available.
Both Positions: The environment is one of a diverse and harmonious group of a dozen different and independent laboratories working on problems of structural biology situated mostly on one floor of the same building.
The starting date is by arrangement, but hopefully as soon as is reasonably possible. It is anticipated that applicants might wish to work in this position for two or more years.
Please send applications including a CV and the names of three referees to Michael Rossmann, Hanley Professor of Biological Sciences, Department of Biological Sciences, Purdue University, West Lafayette, Indiana, 47907-1392, USA. Email address: mgr@indiana.bio.purdue.edu. Phone number: 765-494-4911. Fax number: 765-496-1189.

Postdoctoral Position
Enzyme Crystallography, Mechanisms, Molecular Biology. Send your curriculum vitae to Dr. William Lipscomb, Department of Chemistry and Chemical Biology, 12 Oxford St., Cambridge, MA 02138. Lipscomb@chemistry.harvard.edu, FAX: (617) 495-3330.

Positions Previously Listed
Recent PhD with experience in all aspects of macromolecular crystallography to study proteins that are involved in steroid hormone function, short-chair dehydro-genase enzymes, steroid esterases, steriod binding proteins, steroid receptors and cofactors. Contact: W. L. Duax, HWI, 73 High Street, Buffalo, NY 14203-1196. Phone: 716-856-9600; FAX: 716-852-6086; duax@hwi.buffalo.edu.

Protein crystallographer to work in the new and exciting study of the Targeting Mechanisms of the Protein Kinase C (PKC) and of the cAMP dependent Protein Kinase (PKA). Send CV and contact information for three references to Prof. Nguyen-Huu Xuong, Dept. of Chem. & Biochem., U. Calif., San Diego, 9500 Gilman Dr,, LaJolla, CA 92093-0359. Phone: 619-534-2501; Fax: 619-534-7042; nxuong@ucsd.edu.

Protein crystallographer to study macromolecular complexes and the role of protein-protein interactions in cell cycle regulation, or receptor-mediated cell signaling. Applicants should send curriculum vitae and the names of three references to: Professor Kathryn Ely, The Burnham Institute, 10910 North Torrey Pines Road, La Jolla, CA 92037.